Regular Article CLINICAL TRIALS AND OBSERVATIONS Outcome of patients with abnl(17p) acute myeloid leukemia after allogeneic hematopoietic stem cell transplantation
نویسندگان
چکیده
Hochschule Hannover, Klinik für Hämatologie, Hämostaseologie, Onkologie und Stammzelltransplantation, Hannover, Germany; Department of Hematology, Hospital Universitario La Fe, Valencia University Medical School, Valencia, Spain; Stiftung Deutsche Klinik für Diagnostik GmbH, Zentrum für Blutstammzellund Knochenmarktransplantation, Wiesbaden, Germany; Klinikum der Johann Wolfgang Goethe Universität Frankfurt am Main, Medizinische Klinik II, Frankfurt, Germany; Städtisches Klinikum Nord, 5. Medizinische Klinik, Nürnberg, Germany; Universität Heidelberg, Medizinische Klinik und Poliklinik, Abteilung Innere
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Acute myeloid leukemia (AML) with monosomal karyotype (MK) at diagnosis has been established as a subset of AML patients with very poor prognosis. After the initial publication by the DutchBelgian Hemato-Oncology Cooperative Group and Swiss Group for Clinical Cancer Research (HOVON/SAKK), several studies confirmed the very unfavorable prognostic significance of AMLMK. Recently, Middeke et al re...
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Monosomal karyotype (MK), defined as > 2 autosomal monosomies or a single monosomy in the presence of other structural abnormalities, was confirmed by several studies to convey an extremely poor prognosis in patients with acute myeloid leukemia (AML) with a 4-year overall survival after diagnosis of < 4%. A recent investigation by the Southwest Oncology Group found that the only MK patients ali...
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Reduced-intensity or nonmyeloablative stem cell transplantation (NST) is designed to induce host-versus-graft tolerance by engraftment of donor stem cells. The rationale behind NST is to induce optimal graft-versus-leukemia (GVL) effects for elimination of all malignant cells by donor alloreactive immunocompetent cells as an alternative to standard highdose myeloablative chemoradiotherapy. NST ...
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Allogeneic hematopoietic stem cell transplantation (HSCT) is the most effective treatment for selected hematological malignancies. Its curative potential is largely mediated by an immune-mediated destruction of malignant cells by donor lymphocytes termed graft-versus-leukemia (GVL) effect. However, because of its toxicity, conventional allogeneic HSCT is restricted to younger and fitter patient...
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